PALB2

Biomarkers

PALB2 is involved in the following curated biomarkers.

Name	Biomarker type	Propositions	Statements
PALB2 pathogenic variants	Germline Variant	2	2
PALB2 oncogenic variants	Somatic Variant	2	2

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Type	Biomarker(s)	Cancer type	Therapy(ies)
Sensitivity (+)	PALB2 pathogenic variants	Prostate Adenocarcinoma	Olaparib
Sensitivity (+)	PALB2 oncogenic variants	Prostate Adenocarcinoma	Olaparib
Sensitivity (+)	PALB2 pathogenic variants	Prostate Adenocarcinoma	Enzalutamide, Talazoparib
Sensitivity (+)	PALB2 oncogenic variants	Prostate Adenocarcinoma	Enzalutamide, Talazoparib