Regulatory approval

Published by the Health Service Executive. Approved

First-line treatment of adult patients with unresectable, locally advanced or metastatic oesophageal squamous cell carcinoma (OSCC) whose tumours express programmed death-ligand (PD-L1) with a tumour area positivity (TAP) score >= 5%.

This is written in the approval document.

Reimbursement

Incomplete Reimbursement

Tislelizumab - ODMS; oxaliplatin and capecitabine - N/A

Citation

Tislelizumab and CAPOX Therapy, 2026, version number 1, NCCP National SACT Regimen, NCCP, viewed 02/08/2026, https://healthservice.hse.ie/documents/7463/00924_Tislelizumab_and_CAPOX.pdf

Therapeutic response

Precision oncology relationships for therapeutic response derived from this regulatory approval.

Organizations	Biomarkers	Cancer types	Therapies
HSE (1)	PD-L1 (TAP) >= 5%	Esophageal Squamous Cell Carcinoma	Capecitabine, Oxaliplatin, Tislelizumab