Therapeutic Response Statement (Sensitivity)
This therapeutic response statement supports the relationship that pMMR status confers therapeutic sensitivity to Durvalumab, Olaparib in patients with Endometrial Carcinoma.
The European Medicines Agency (EMA) has authorized olaparib in combination with durvalumab for the maintenance treatment of adult patients with primary advanced or recurrent endometrial cancer that is mismatch repair proficient (pMMR) whose disease has not progressed on first-line treatment with durvalumab in combination with carboplatin and paclitaxel.
This statement is based on a regulatory approval from the European Medicines Agency:
Lynparza in combination with durvalumab is indicated for the maintenance treatment of adult patients with primary advanced or recurrent endometrial cancer that is mismatch repair proficient (pMMR) whose disease has not progressed on first-line treatment with durvalumab in combination with carboplatin and paclitaxel.