Therapeutic Response Statement (Sensitivity)

This therapeutic response statement supports the relationship that CD20 + status confers therapeutic sensitivity to Cyclophosphamide, Doxorubicin, Etoposide, Prednisolone, Rituximab, Vincristine in patients with Non-Hodgkin Lymphoma.

The Republic of Ireland's Health Service Executive (HSE) has approved dose adjusted rituximab in combination with etoposide, prednisolone, doxorubicin, cyclophosphamide and vincristine (DA-R EPOCH) therapy for reimbursement as a treatment option for the treatment of patients with CD20 positive diffuse large B-cell Non Hodgkins Lymphoma (NHL).

This statement is based on a regulatory approval from the Health Service Executive:

Treatment of patients with CD20 positive diffuse large B-cell Non Hodgkins lymphoma (NHL).

Citation

Dose Adjusted riTUXimab, Etoposide, prednisoLONE, DOXOrubicin, cycloPHOSphamide and vinCRIStine (DA-R EPOCH) Therapy, 2023, version number 4, NCCP National SACT Regimen, NCCP, viewed 21/07/2024, https://www.hse.ie/eng/services/list/5/cancer/profinfo/chemoprotocols/lymphoma-myeloma/355-dose-adjusted-r-epoch-therapy.pdf