Therapeutic Response Statement (Sensitivity)

This therapeutic response statement supports the relationship that CD20 + status confers therapeutic sensitivity to Cyclophosphamide, Doxorubicin, Prednisolone, Rituximab, Vinorelbine in patients with Non-Hodgkin Lymphoma.

The Republic of Ireland's Health Service Executive (HSE) has approved cyclophosphamide in combination with doxorubicin, vincristine, and prednisolone (CHOP Therapy) (14 days) for the treatment of non-hodgkin's lymphoma (NHL). The therapy regimen further states that rituximab is to be included for the treatment of CD20 positive patients.

This statement is based on a regulatory approval from the Health Service Executive:

Treatment of Non Hodgkin's Lymphoma (NHL). Rituximab to be included in CD20 positive patients.

Citation

(*riTUXimab) cycloPHOSphamide, DOXOrubicin, vinCRIStine and prednisoLONE (*R)-CHOP Therapy - 14 day, 2024, version number 5a, NCCP National SACT Regimen, NCCP, viewed 21/07/2024, https://www.hse.ie/eng/services/list/5/cancer/profinfo/chemoprotocols/lymphoma-myeloma/409.pdf