ABL1 p.T315I
About
Gene context: ABL1
Biomarker Type: Somatic Variant
Present: True
Chromosome: 9
Start Position: 133748283
End Position: 133748283
Reference Allele: C
Alternate Allele: T
Cdna Change: c.944C>T
Protein Change: p.T315I
Variant Annotation: Missense
Exon: 5
Rsid: rs121913459
Hgvsg: 9:g.133748283C>T
Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
Therapeutic response
Precision oncology relationships for therapeutic response involving this biomarker.| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | ABL1 p.T315I, BCR::ABL1 | Chronic Myelogenous Leukemia | Asciminib | |
| Sensitivity (+) | ABL1 p.T315I, BCR::ABL1 | Acute Lymphoid Leukemia | Ponatinib | |
| Sensitivity (+) | ABL1 p.T315I | Chronic Myelogenous Leukemia | Ponatinib | |
| Sensitivity (+) | ABL1 p.T315I | Chronic Myelogenous Leukemia | Ponatinib | |
| Sensitivity (+) | ABL1 p.T315I, BCR::ABL1 | Acute Lymphoid Leukemia | Ponatinib | |
| Sensitivity (+) | ABL1 p.T315I | Chronic Myelogenous Leukemia | Ponatinib | |
| Sensitivity (+) | ABL1 p.T315I, BCR::ABL1 | Acute Lymphoid Leukemia | Ponatinib |