AKT1 somatic variants
About
Gene context: AKT1
Biomarker Type: Somatic Variant
Present: True
Chromosome: 14
Requires Oncogenic: True
Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
Therapeutic response
Precision oncology relationships for therapeutic response involving this biomarker.
| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | AKT1 somatic variants, ER positive, HER2-negative | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| Sensitivity (+) | AKT1 somatic variants, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| Sensitivity (+) | AKT1 somatic variants, ER positive, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| Sensitivity (+) | AKT1 somatic variants, ER positive, HER2-negative | Invasive Breast Carcinoma | Capivasertib, Fulvestrant |