KRAS p.G12C
About
Gene context: KRAS
Biomarker Type: Somatic Variant
Present: True
Chromosome: 12
Start Position: 25398285
End Position: 25398285
Reference Allele: C
Alternate Allele: A
Cdna Change: c.34G>T
Protein Change: p.G12C
Variant Annotation: Missense
Exon: 2
Rsid: rs121913530
Hgvsg: 12:g.25398285C>A
Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
Therapeutic response
Precision oncology relationships for therapeutic response involving this biomarker.| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | KRAS p.G12C | Non-Small Cell Lung Cancer | Adagrasib | |
| Sensitivity (+) | KRAS p.G12C | Non-Small Cell Lung Cancer | Sotorasib | |
| Sensitivity (+) | KRAS p.G12C | Colorectal Adenocarcinoma | Adagrasib, Cetuximab | |
| Sensitivity (+) | KRAS p.G12C | Non-Small Cell Lung Cancer | Adagrasib | |
| Sensitivity (+) | KRAS p.G12C | Non-Small Cell Lung Cancer | Sotorasib |