EGFR p.L858R

About

Biomarker type: Somatic variant

Gene context: EGFR

HGVS.p: NP_005219.2:p.Leu858Arg

Mappings
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Therapeutic response

Precision oncology relationships for therapeutic response involving this biomarker.

Organizations Biomarkers Cancer types Therapies
FDA (1) EGFR p.L858R Non-Small Cell Lung Cancer Dacomitinib
FDA (1) EGFR p.L858R Non-Small Cell Lung Cancer Erlotinib
FDA (1) EGFR p.L858R Non-Small Cell Lung Cancer Gefitinib
EMA (2) FDA (3) HSE (1) EGFR p.L858R Non-Small Cell Lung Cancer Osimertinib
FDA (1) EGFR p.L858R Non-Small Cell Lung Cancer Cisplatin, Osimertinib, Pemetrexed
FDA (1) EGFR p.L858R Non-Small Cell Lung Cancer Carboplatin, Osimertinib, Pemetrexed
FDA (1) EGFR p.L858R Non-Small Cell Lung Cancer Erlotinib, Ramucirumab
EMA (3) FDA (2) EGFR p.L858R Non-Small Cell Lung Cancer Amivantamab, Lazertinib
EMA (1) FDA (1) EGFR p.L858R Non-Small Cell Lung Cancer Amivantamab, Carboplatin, Pemetrexed
EMA (1) EGFR p.L858R Non-Small Cell Lung Cancer Bevacizumab, Erlotinib
EMA (1) EGFR p.L858R Non-Small Cell Lung Cancer Cisplatin, Osimertinib
EMA (1) EGFR p.L858R Non-Small Cell Lung Cancer Carboplatin, Osimertinib
FDA (1) EGFR p.L858R Non-Small Cell Lung Cancer Datopotamab deruxtecan
EMA (1) EGFR p.L858R Non-Small Cell Lung Cancer Aumolertinib