CDK12
About
Location: 17q12
Mappings
Biomarkers
CDK12 is involved in the following curated biomarkers.| Name | Biomarker type | Propositions | Statements |
|---|---|---|---|
| CDK12 pathogenic variants | Germline Variant | 3 | 3 |
| CDK12 oncogenic variants | Somatic Variant | 3 | 3 |
Therapeutic response
Precision oncology relationships for therapeutic response involving this gene.| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | CDK12 pathogenic variants | Prostate Adenocarcinoma | Abiraterone acetate, Niraparib, Prednisone | |
| Sensitivity (+) | CDK12 oncogenic variants | Acute Myeloid Leukemia | Cytarabine, Daunorubicin, Midostaurin | |
| Sensitivity (+) | CDK12 pathogenic variants | Prostate Adenocarcinoma | Olaparib | |
| Sensitivity (+) | CDK12 oncogenic variants | Prostate Adenocarcinoma | Olaparib | |
| Sensitivity (+) | CDK12 oncogenic variants | Prostate Adenocarcinoma | Enzalutamide, Talazoparib | |
| Sensitivity (+) | CDK12 pathogenic variants | Prostate Adenocarcinoma | Enzalutamide, Talazoparib |