Acute Myeloid Leukemia

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OncoTree: Acute Myeloid Leukemia (oncotree:AML)

Therapeutic response

Precision oncology relationships for therapeutic response involving this cancer type.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) CD33 + Acute Myeloid Leukemia Cytarabine, Daunorubicin, Gemtuzumab ozogamicin
Sensitivity (+) FLT3-ITD Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) IDH1 p.R132C Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) IDH1 p.R132G Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) IDH1 p.R132H Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) IDH1 p.R132L Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) IDH1 p.R132S Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) FLT3-ITD Acute Myeloid Leukemia Gilteritinib
Sensitivity (+) FLT3 p.D835Y Acute Myeloid Leukemia Gilteritinib
Sensitivity (+) IDH2 p.R140Q Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R140L Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R140G Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R140W Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172K Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172M Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172G Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172S Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172W Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH1 p.R132C Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132C Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132G Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132G Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132H Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132H Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132L Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132L Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132S Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132S Acute Myeloid Leukemia Ivosidenib
Sensitivity (+) IDH1 p.R132C Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) IDH1 p.R132G Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) IDH1 p.R132H Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) IDH1 p.R132L Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) IDH1 p.R132S Acute Myeloid Leukemia Azacitidine, Ivosidenib
Sensitivity (+) FLT3-ITD Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3 p.D835Y Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3 p.D835A Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3 p.D835E Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3 p.D835H Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3 p.D835N Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3 p.D835S Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3 p.D835V Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3 p.I836del Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) CDK12 oncogenic variants Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) IDH1 p.R132C Acute Myeloid Leukemia Olutasidenib
Sensitivity (+) IDH1 p.R132G Acute Myeloid Leukemia Olutasidenib
Sensitivity (+) IDH1 p.R132H Acute Myeloid Leukemia Olutasidenib
Sensitivity (+) IDH1 p.R132L Acute Myeloid Leukemia Olutasidenib
Sensitivity (+) IDH1 p.R132S Acute Myeloid Leukemia Olutasidenib
Sensitivity (+) t(KMT2A;v) Acute Myeloid Leukemia Revumenib
Sensitivity (+) FLT3-ITD Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+) FLT3-ITD Acute Myeloid Leukemia Midostaurin
Sensitivity (+) FLT3-ITD Acute Myeloid Leukemia Midostaurin