IDH2 p.R172S
About
Gene context: IDH2
Biomarker Type: Somatic Variant
Present: True
Chromosome: 15
Start Position: 90631837
End Position: 90631837
Reference Allele: C
Alternate Allele: G
Cdna Change: c.516G>C
Protein Change: p.R172S
Variant Annotation: Missense
Exon: 4
Rsid: rs1057519736
Hgvsg: 15:g.90631837C>G
Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
Therapeutic response
Precision oncology relationships for therapeutic response involving this biomarker.| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | IDH2 p.R172S | Acute Myeloid Leukemia | Enasidenib | |
| Sensitivity (+) | IDH2 p.R172S | Astrocytoma | Vorasidenib | |
| Sensitivity (+) | IDH2 p.R172S | Oligodendroglioma | Vorasidenib |