FLT3 p.D835S
About
Gene context: FLT3
Biomarker Type: Somatic Variant
Present: True
Chromosome: 13
Start Position: 28592641
End Position: 28592642
Reference Allele: TC
Alternate Allele: CT
Cdna Change: c.2503_2504delinsAG
Protein Change: p.D835S
Variant Annotation: Missense
Exon: 20
Rsid: ENST00000241453.7:c.2503_2504delinsAG
Hgvsg: 13:g.28592641_28592642delinsCT
Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
Therapeutic response
Precision oncology relationships for therapeutic response involving this biomarker.| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | FLT3 p.D835S | Acute Lymphoid Leukemia | Gilteritinib | |
| Sensitivity (+) | FLT3 p.D835S | Acute Myeloid Leukemia | Cytarabine, Daunorubicin, Midostaurin |