FLT3

Biomarkers

FLT3 is involved in the following curated biomarkers.

Name	Biomarker type	Propositions	Statements
FLT3-ITD	Somatic Variant	5	7
FLT3 p.D835Y	Somatic Variant	3	3
FLT3 p.D835A	Somatic Variant	2	2
FLT3 p.D835E	Somatic Variant	2	2
FLT3 p.D835H	Somatic Variant	2	2
FLT3 p.D835N	Somatic Variant	2	2
FLT3 p.D835S	Somatic Variant	2	2
FLT3 p.D835V	Somatic Variant	2	2
FLT3 p.I836del	Somatic Variant	1	1
FLT3 p.I836N	Somatic Variant

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Type	Biomarker(s)	Cancer type	Therapy(ies)
Sensitivity (+)	FLT3-ITD	Acute Lymphoid Leukemia	Gilteritinib
Sensitivity (+)	FLT3 p.D835Y	Acute Lymphoid Leukemia	Gilteritinib
Sensitivity (+)	FLT3 p.D835A	Acute Lymphoid Leukemia	Gilteritinib
Sensitivity (+)	FLT3 p.D835E	Acute Lymphoid Leukemia	Gilteritinib
Sensitivity (+)	FLT3 p.D835H	Acute Lymphoid Leukemia	Gilteritinib
Sensitivity (+)	FLT3 p.D835N	Acute Lymphoid Leukemia	Gilteritinib
Sensitivity (+)	FLT3 p.D835S	Acute Lymphoid Leukemia	Gilteritinib
Sensitivity (+)	FLT3 p.D835V	Acute Lymphoid Leukemia	Gilteritinib
Sensitivity (+)	FLT3-ITD	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3 p.D835Y	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3 p.D835A	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3 p.D835E	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3 p.D835H	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3 p.D835N	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3 p.D835S	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3 p.D835V	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3 p.I836del	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3-ITD	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3-ITD	Acute Myeloid Leukemia	Gilteritinib
Sensitivity (+)	FLT3 p.D835Y	Acute Myeloid Leukemia	Gilteritinib
Sensitivity (+)	FLT3-ITD	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
Sensitivity (+)	FLT3-ITD	Acute Myeloid Leukemia	Midostaurin
Sensitivity (+)	FLT3-ITD	Acute Myeloid Leukemia	Midostaurin