IDH1 p.R132H
About
Gene context: IDH1
Biomarker Type: Somatic Variant
Present: True
Chromosome: 2
Start Position: 209113112
End Position: 209113112
Reference Allele: C
Alternate Allele: T
Cdna Change: c.395G>A
Protein Change: p.R132H
Variant Annotation: Missense
Exon: 4
Rsid: rs121913500
Hgvsg: 2:g.209113112C>T
Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
Therapeutic response
Precision oncology relationships for therapeutic response involving this biomarker.| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | IDH1 p.R132H | Acute Myeloid Leukemia | Ivosidenib | |
| Sensitivity (+) | IDH1 p.R132H | Acute Myeloid Leukemia | Azacitidine, Ivosidenib | |
| Sensitivity (+) | IDH1 p.R132H | Acute Myeloid Leukemia | Ivosidenib | |
| Sensitivity (+) | IDH1 p.R132H | Myelodysplastic Syndromes | Ivosidenib | |
| Sensitivity (+) | IDH1 p.R132H | Cholangiocarcinoma | Ivosidenib | |
| Sensitivity (+) | IDH1 p.R132H | Acute Myeloid Leukemia | Olutasidenib | |
| Sensitivity (+) | IDH1 p.R132H | Astrocytoma | Vorasidenib | |
| Sensitivity (+) | IDH1 p.R132H | Oligodendroglioma | Vorasidenib | |
| Sensitivity (+) | IDH1 p.R132H | Acute Myeloid Leukemia | Azacitidine, Ivosidenib | |
| Sensitivity (+) | IDH1 p.R132H | Cholangiocarcinoma | Ivosidenib |