IDH1

About

Location: 2q34

Mappings

HGNC: HGNC:5382

Ensembl: ENSG00000138413

NCBI: 3417

Refseq: NM_005896.4

Biomarkers

IDH1 is involved in the following curated biomarkers.

Name	Biomarker type	Propositions	Statements
IDH1 p.R132C	Somatic Variant	7	10
IDH1 p.R132G	Somatic Variant	7	10
IDH1 p.R132H	Somatic Variant	7	10
IDH1 p.R132L	Somatic Variant	7	10
IDH1 p.R132S	Somatic Variant	7	10

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Type	Biomarker(s)	Cancer type	Therapy(ies)
Sensitivity (+)	IDH1 p.R132C	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132G	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132H	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132L	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132S	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132C	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132G	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132H	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132L	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132S	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132C	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132G	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132H	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132L	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132S	Acute Myeloid Leukemia	Ivosidenib
Sensitivity (+)	IDH1 p.R132C	Myelodysplastic Syndromes	Ivosidenib
Sensitivity (+)	IDH1 p.R132G	Myelodysplastic Syndromes	Ivosidenib
Sensitivity (+)	IDH1 p.R132H	Myelodysplastic Syndromes	Ivosidenib
Sensitivity (+)	IDH1 p.R132L	Myelodysplastic Syndromes	Ivosidenib
Sensitivity (+)	IDH1 p.R132S	Myelodysplastic Syndromes	Ivosidenib
Sensitivity (+)	IDH1 p.R132C	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132G	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132H	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132L	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132S	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132C	Acute Myeloid Leukemia	Olutasidenib
Sensitivity (+)	IDH1 p.R132G	Acute Myeloid Leukemia	Olutasidenib
Sensitivity (+)	IDH1 p.R132H	Acute Myeloid Leukemia	Olutasidenib
Sensitivity (+)	IDH1 p.R132L	Acute Myeloid Leukemia	Olutasidenib
Sensitivity (+)	IDH1 p.R132S	Acute Myeloid Leukemia	Olutasidenib
Sensitivity (+)	IDH1 p.R132C	Astrocytoma	Vorasidenib
Sensitivity (+)	IDH1 p.R132G	Astrocytoma	Vorasidenib
Sensitivity (+)	IDH1 p.R132H	Astrocytoma	Vorasidenib
Sensitivity (+)	IDH1 p.R132L	Astrocytoma	Vorasidenib
Sensitivity (+)	IDH1 p.R132S	Astrocytoma	Vorasidenib
Sensitivity (+)	IDH1 p.R132C	Oligodendroglioma	Vorasidenib
Sensitivity (+)	IDH1 p.R132G	Oligodendroglioma	Vorasidenib
Sensitivity (+)	IDH1 p.R132H	Oligodendroglioma	Vorasidenib
Sensitivity (+)	IDH1 p.R132L	Oligodendroglioma	Vorasidenib
Sensitivity (+)	IDH1 p.R132S	Oligodendroglioma	Vorasidenib
Sensitivity (+)	IDH1 p.R132C	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132G	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132H	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132L	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132S	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
Sensitivity (+)	IDH1 p.R132C	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132G	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132H	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132L	Cholangiocarcinoma	Ivosidenib
Sensitivity (+)	IDH1 p.R132S	Cholangiocarcinoma	Ivosidenib