PDGFRA
About
Location: 4q12
Mappings
Biomarkers
PDGFRA is involved in the following curated biomarkers.| Name | Biomarker type | Propositions | Statements |
|---|---|---|---|
| PDGFRA p.D842V | Somatic Variant | 1 | 2 |
| PDGFRA rearrangements | Rearrangement | 2 | 3 |
| FIP1L1::PDGFRA | Rearrangement | 2 | 3 |
Therapeutic response
Precision oncology relationships for therapeutic response involving this gene.| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | PDGFRA p.D842V | Gastrointestinal Stromal Tumor | Avapritinib | |
| Sensitivity (+) | PDGFRA rearrangements | Myelodysplastic Syndromes | Imatinib | |
| Sensitivity (+) | FIP1L1::PDGFRA | Chronic Eosinophilic Leukemia, NOS | Imatinib | |
| Sensitivity (+) | FIP1L1::PDGFRA | Gastrointestinal Stromal Tumor | Imatinib | |
| Sensitivity (+) | PDGFRA p.D842V | Gastrointestinal Stromal Tumor | Avapritinib | |
| Sensitivity (+) | PDGFRA rearrangements | Myelodysplastic Syndromes | Imatinib | |
| Sensitivity (+) | PDGFRA rearrangements | Myeloproliferative Neoplasm | Imatinib | |
| Sensitivity (+) | FIP1L1::PDGFRA | Chronic Eosinophilic Leukemia, NOS | Imatinib |