TP53

Biomarkers

TP53 is involved in the following curated biomarkers.

Name	Biomarker type	Propositions	Statements
TP53 somatic variants	Somatic Variant	6	8
TP53 deletion	Copy Number	6	8
Wild type TP53	Wild type	1	2

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Type	Biomarker(s)	Cancer type	Therapy(ies)
Sensitivity (+)	TP53 somatic variants	Chronic Lymphocytic Leukemia	Venetoclax
Sensitivity (+)	TP53 deletion	Chronic Lymphocytic Leukemia	Venetoclax
Sensitivity (+)	Wild type TP53	Chronic Lymphocytic Leukemia	Venetoclax
Sensitivity (+)	TP53 deletion	Chronic Lymphocytic Leukemia	Idelalisib, Rituximab
Sensitivity (+)	TP53 somatic variants	Chronic Lymphocytic Leukemia	Idelalisib, Rituximab
Sensitivity (+)	TP53 somatic variants	Chronic Lymphocytic Leukemia	Venetoclax
Sensitivity (+)	TP53 deletion	Chronic Lymphocytic Leukemia	Venetoclax
Sensitivity (+)	Wild type TP53	Chronic Lymphocytic Leukemia	Venetoclax
Sensitivity (+)	TP53 somatic variants	Chronic Lymphocytic Leukemia	Zanubrutinib
Sensitivity (+)	TP53 deletion	Chronic Lymphocytic Leukemia	Zanubrutinib
Sensitivity (+)	TP53 somatic variants	Chronic Lymphocytic Leukemia	Acalabrutinib
Sensitivity (+)	TP53 deletion	Chronic Lymphocytic Leukemia	Acalabrutinib
Sensitivity (+)	TP53 somatic variants	Chronic Lymphocytic Leukemia	Ibrutinib
Sensitivity (+)	TP53 deletion	Chronic Lymphocytic Leukemia	Ibrutinib
Sensitivity (+)	TP53 somatic variants	Chronic Lymphocytic Leukemia	Idelalisib, Rituximab
Sensitivity (+)	TP53 deletion	Chronic Lymphocytic Leukemia	Idelalisib, Rituximab
Sensitivity (+)	TP53 somatic variants	Chronic Lymphocytic Leukemia	Idelalisib, Ofatumumab
Sensitivity (+)	TP53 deletion	Chronic Lymphocytic Leukemia	Idelalisib, Ofatumumab