Regulatory approval

Published by the Food and Drug Administration.

The U.S. Food and Drug Administration (FDA) has granted approval to vorasidenib for the treatment of adult and pediatric patients 12 years and older with Grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery including biopsy, sub-total resection, or gross total resection.

This is written in the approval document as:

VORANIGO is an isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2) inhibitor indicated for the treatment of adult and pediatric patients 12 years and older with Grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery including biopsy, sub-total resection, or gross total resection.

Citation

Servier Pharmaceuticals LLC. Voranigo (vorasidenib) [package insert]. U.S. Food and Drug Administration website. https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/218784s000lbl.pdf. Revised August 2024. Accessed October 30, 2024.

Therapeutic response

Precision oncology relationships for therapeutic response derived from this regulatory approval.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) IDH1 p.R132C Astrocytoma Vorasidenib
Sensitivity (+) IDH1 p.R132G Astrocytoma Vorasidenib
Sensitivity (+) IDH1 p.R132H Astrocytoma Vorasidenib
Sensitivity (+) IDH1 p.R132L Astrocytoma Vorasidenib
Sensitivity (+) IDH1 p.R132S Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172K Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172M Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172G Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172S Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172W Astrocytoma Vorasidenib
Sensitivity (+) IDH1 p.R132C Oligodendroglioma Vorasidenib
Sensitivity (+) IDH1 p.R132G Oligodendroglioma Vorasidenib
Sensitivity (+) IDH1 p.R132H Oligodendroglioma Vorasidenib
Sensitivity (+) IDH1 p.R132L Oligodendroglioma Vorasidenib
Sensitivity (+) IDH1 p.R132S Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172K Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172M Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172G Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172S Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172W Oligodendroglioma Vorasidenib